Is this treatment available in my Florida city?

Yes. Reset My Vitality is a Florida-licensed telehealth practice serving every city in the state, including Miami, Miami Beach, Fort Lauderdale, West Palm Beach, Boca Raton, Orlando, Tampa, Jacksonville, and Naples. Medication ships directly to your door.

Do I pay if I am not prescribed?

No. You only pay if a Florida-licensed clinician determines the treatment is appropriate and writes a prescription. Consultations are risk-free.

How fast will I get started?

Most patients complete intake in under 10 minutes and hear back from a clinician within 1–3 business days. Medication typically arrives within a week of approval.

Is this covered by insurance?

Reset My Vitality is cash-pay so pricing stays transparent and predictable. We can provide a superbill on request for possible out-of-network reimbursement.

Is telehealth as safe as an in-person visit?

For the conditions we treat, peer-reviewed evidence shows telehealth outcomes are equivalent to — and often better than — traditional office care, with significantly higher adherence and follow-up rates.

How Tadalafil (Cialis) Works for ED in Florida

Tadalafil is the long-acting PDE5 inhibitor behind Cialis. Here is how it works, when to take it, and how on-demand vs daily dosing compare.

Tadalafil — the generic for Cialis — is the long-acting member of the PDE5 inhibitor family. It works through the same mechanism as sildenafil, but the way it fits into real life is very different because its effects can last well over a day from a single dose. ^[1]

The mechanism in plain English

When you're aroused, your nerves release nitric oxide, which boosts a messenger called cGMP. cGMP relaxes the smooth muscle in penile blood vessels so blood can fill in. An enzyme called PDE5 normally breaks cGMP down. Tadalafil blocks PDE5, so cGMP sticks around longer and erections become firmer and easier to sustain. You still need sexual stimulation — tadalafil only sets the stage. ^[2]

What makes tadalafil different

Half-life of about 17.5 hours — effects can last up to 36 hours per dose.
Food and alcohol don't meaningfully delay absorption.
Comes in on-demand strengths (10 mg, 20 mg) and daily low-dose strengths (2.5 mg, 5 mg).
FDA-approved for both ED and benign prostatic hyperplasia (BPH).

On-demand vs daily dosing

On-demand tadalafil (10–20 mg) is taken at least 30 minutes before sex. Daily tadalafil (2.5–5 mg) is taken every morning so your body always has a therapeutic level on board — meaning sex doesn't need to be planned around a pill. In clinic, daily dosing is what most men switch to once they realize how much pressure it takes off intimacy. ^[3]

What to expect

Roughly 70–80% of men respond well to tadalafil. With on-demand dosing, you typically feel an effect within 30–45 minutes, with a wide 36-hour window. With daily dosing, the effect builds over the first 5–7 days and becomes more reliable from there. ^[1]

Side effects

The most common ones are headache, flushing, indigestion, and — uniquely for tadalafil — mild back or muscle aches that show up 12–24 hours after dosing. Most resolve as your body adjusts. If they don't, a dose reduction usually fixes it.

When tadalafil isn't safe

Never combine tadalafil with nitrates or guanylate cyclase stimulators (like riociguat). Tell your clinician about all alpha-blockers and blood pressure medications. Severe heart, liver, or kidney disease may rule it out, which is why we screen carefully before prescribing.

The bottom line

If spontaneity matters to you, tadalafil — especially daily low-dose — is hard to beat. Try it for 4–6 weeks, message us with how it's going, and we'll fine-tune the dose until it's the right fit.

Available across Florida

Reset My Vitality is a Florida-licensed telehealth practice. The treatments covered in this guide are available to patients statewide, with medication shipped directly to your door. Explore the program for your city:

Key Clinical Studies

A short, responsible summary of recent peer-reviewed research relevant to this topic. This is for education only, not medical advice.

Effect of phosphodiesterase-type 5 inhibitors on erectile function: an overview of systematic reviews and meta-analyses

BMJ Open · 2021

Key finding: PDE5 inhibitors including tadalafil consistently improved erectile function across systematic reviews and meta-analyses.

Why it matters: Directly supports tadalafil as first-line oral therapy for erectile dysfunction.

View study

Associations between PDE5 inhibitors and vascular function

Systematic Reviews · 2025

Key finding: RCT meta-analysis confirmed PDE5 inhibitors improve vascular function, consistent with tadalafil's long-acting profile.

Why it matters: Explains tadalafil's 36-hour window and supports its long-term cardiovascular safety profile.

View study

Scientific References

Peer-reviewed studies and reviews cited in this article.

[1]Huang Y, et al. Effect of phosphodiesterase-type 5 inhibitors on erectile function: an overview of systematic reviews and meta-analyses. BMJ Open. 2021;11(8):e047396. View study
[2]Zhang Y, et al. Associations between phosphodiesterase type 5 inhibitors and vascular function: a systematic review and meta-analysis on randomized-controlled trials. Systematic Reviews. 2025. View study
[3]Pyrgidis N, et al. Assessment of Combination Therapies vs Monotherapy for Erectile Dysfunction: A Systematic Review and Meta-analysis. JAMA Network Open. 2021;4(2):e2036337. View study

How Tadalafil (Cialis) Works for ED in Florida | Mechanism Guide